Is Similac Infant Formula Better Compared To Enfamil?

Enfamil is a brand of infant formula made by Mead Johnson Nutrition. It was the first company to make an infant formula in the United States. These formulas have been around since 1922 and are one of the most popular brands for babies, especially for those with milk allergies such as cow’s milk allergy, or lactose intolerance. The company also makes other formulas such as Enfagrow, Enfamil Nutramigen, and Neosure. Enfamil Nutramigen is a hypoallergenic formula to prevent cow’s milk protein allergy.

Cow’s milk protein allergy is the most common allergy in babies. Worry not, allergy to cow’s milk will eventually go away, the brand is known to be the closest formula to breast milk because Lactoferrin and MFGM are found in breast milk which they managed to include in their formulation. Even though we all know that nothing beats the nutrition of breast milk and that it’s still the best for babies, it’s important to know that we have a close option for breast milk benefits. 

Similac is another popular brand of infant formula that’s been around since 1934, and it has been in more households than any other infant formula on the market today. Similac offers a wide range of products, including Similac Advance Infant Formula, Similac, and Soy Isomil. Similac Advance infant formula is a nutritionally complete, milk-based infant formula good for a baby’s first year. Similac Advance infant formula is easy to digest and supports brain and eye development. Similac soy Isomil is an easy-to-digest powdered formula for infants with fussiness and gas. It is the only soy formula clinically proven to help the immune system.

The Similac soy Isomil powdered formula is designed for babies with lactose intolerance and galactosemia. Similac Soy Isomil is a specialized formula designed for infants with soy protein sensitivity, providing a suitable alternative to cow’s milk-based formulas. Similac Soy Isomil is a popular choice for parents seeking a soy-based formula option for their infants who may have lactose intolerance or sensitivity to cow’s milk protein

Is Enfamil considered the superior choice when it comes to baby formula?

In this article, Family Hype will take an in-depth look at Enfamil infant formula and Similac infant formula to help you decide which is the best infant formula.  

Enfamil Vs. Similac: Exploring The Differences And Finding The Best Option

Enfamil vs Similac? Which one to pick for your infant? Enfamil and Similac are two of the most popular infant formula brands in the United States. However, when it comes to Enfamil vs Similac, they have a lot of differences in their formulas, ingredients, and packaging.


Similac states that its milk formula lowers spit-up episodes by 54%, whereas Emfamil asserts that its milk formula reduces spit-up episodes by 50%. Have you decided between Enfamil and Similac?


Both formulas for picky babies use different protein sources—Pro-Total Similac’s Comfort has 100 percent whey protein concentrate solids, while Enfamil’s Gentlease milk formula contains 60 percent whey protein concentrate and 40 percent casein. Enfamil Gentlease also has some corn syrup solids; it has roughly 10g of corn syrup solids per 5 oz. Corn syrup solids are recognized as safe to be used in infant formulas by the FDA. 

Both Enfamil and Similac offer a wide range of options to meet the diverse needs of infants, making the decision between Enfamil vs. Similac an important one for parents to consider.

Enfamil Infant Formula

Enfamil NeuroPro (Enfamil’s regular milk-based formula) has a milk fat globule membrane. If you’re not aware of milk fat globule membrane, milk fat globule membrane can be found in breast milk or human milk. The milk fat globule membrane can help support a baby’s cognitive development. As a result, this milk formula matches breast milk more precisely and has slightly more significant quantities of specific fatty acids.

Regardless of brand, all infant formulas marketed in the United States must meet certain nutrient criteria specified by the United States Food and Drug Administration (FDA) to guarantee your infant gets the nutrients they require to grow and flourish. Both Enfamil infant formula and Similac infant formula are great infant formulas for your infant.

Many mothers often wonder, “Is Enfamil infant formula better than Similac?” when considering the best infant formula for their little ones. This comparison between Enfamil and Similac Alimentum encompasses various factors such as the composition of infant formulas, including partially hydrolyzed nonfat milk, milk fat globule membrane, corn syrup solids, whey protein concentrate solids, and vegetable oils. The milk fat globule membrane is a protective layer surrounding the fat droplets in breast milk and plays a vital role in delivering essential nutrients to the infant.

Mothers also weigh the benefits of breast milk against these commercially available formulas. Enfamil and Similac offer a range of options, including hypoallergenic formulas like Enfamil Nutramigen and Similac Alimentum for babies with specific dietary needs. Factors such as cow’s milk, soy formula, rice starch, whey protein concentrate solids, and artificial growth hormones are also taken into consideration.

Artificial growth hormones are not used in the production of reputable infant formulae brands like Enfamil and Similac to ensure the safety and well-being of babies. Rice starch, derived from rice grains, is commonly used as a thickening agent in various food products, including sauces, soups, and puddings.

While both Enfamil Nutramigen and Similac Alimentum provide a powdered formula that strives to mimic the nutritional qualities of human milk, the decision ultimately rests on the preferences and needs of each infant. Consulting with healthcare professionals can help determine the most suitable choice between Enfamil and Similac, taking into account factors such as infant allergies, cow’s milk formula tolerability, and overall nutritional requirements.

Both have dedicated customer support services to assist parents with any questions or concerns regarding their formulas. Cow’s milk formula is a popular choice for infants who do not have any specific dietary restrictions or allergies. One advantage of cow’s milk formula is its similarity to breast milk in terms of nutritional composition.

Cow’s milk is a common and widely consumed beverage worldwide, known for its rich source of calcium, protein, and other essential nutrients that support bone health and overall growth and development in individuals of all ages. Cow’s milk is a versatile ingredient in various culinary creations, from creamy desserts to savory dishes, adding a rich and delicious flavor.

Many people enjoy a refreshing glass of cold cow’s milk as a nutritious beverage to accompany their meals or as a standalone thirst quencher. Cow’s milk is a staple ingredient in the production of numerous dairy-based products, contributing to the economy and supporting livelihoods in rural farming communities.

Ultimately, the goal is to provide infants with a milk formula that meets their nutritional needs, supports healthy growth, and ensures their well-being. It’s important to remember that individual babies may respond differently to different formulas, so what works best for one infant may not be the same for another.

Similac Baby Formula Or Enfamil Baby Formula?

Which milk brand is superior: Enfamil or Similac?

The Better Infant Formula

When it comes to Enfamil vs Similac who wins? Which is among the Enfamil vs Similac? Most parents in the U.S. feed their infants with standard milk-based infant formulae when they are not nursing. However, the American Academy of Pediatrics (AAP) suggests giving iron-fortified, milk-based formulations to babies fed by milk.

Similac Advance is an iron-fortified milk-based infant milk that also contains lutein, vitamin E, and omega-3 fatty acid docosahexaenoic acid (DHA) to further support infant neurodevelopment. Similac Advance has an exclusive blend of ingredients for a baby’s brain and eye development. Similac Advance is also easy to digest and has no palm olein oil. Aside from that, the Similac Advance also has no artificial growth hormones making Similac Advance the #1 brand that hospitals recommend.

Although it’s important to note that studies demonstrate the ingredient naturally appears in breast milk or human milk and therefore has no adverse effects on developing newborns, the brand advertises that it excludes palm olein oil intending to boost calcium absorption. Human milk is often considered the ideal source of nutrition for infants due to its unique composition and benefits. Breast milk provides numerous advantages for both the infant and the mother, as human milk contains essential nutrients and antibodies that support the baby’s immune system and overall health.

Human milk is custom-made for each infant, adapting its composition to meet the changing needs of the growing infant. The World Health Organization (WHO) recommends exclusive breast milk for the first six months of a baby’s life, followed by continued breast milk alongside the introduction of complementary foods.

Similac Advance’s key ingredients include nonfat milk, lactose, whey protein concentrate solids, corn syrup solids, high oleic safflower oil, soy oil, coconut oil, and galactooligosaccharides (prebiotics). Nonfat milk as an infant milk ingredient can be beneficial for babies since nonfat milk is a great source of protein and carbohydrates; the catch is without fat. It is only recommended to give nonfat milk to infants once their growth is steady because fat, which is not included in nonfat milk, is still important to be taken.

Enfamil NeuroPro stands apart because it focuses on fatty acids that support the brain and eyes. To promote brain health, the World Health Organization advises newborn formulae to contain between. Three percent and.5 percent DHA. This formulation has a.32 percent content.

Nonfat milk, lactose, vegetable oil (palm olein, coconut, soy, and high oleic sunflower oils), whey protein concentrate, and whey protein-lipid concentrate are Enfamil NeuroPro’s main ingredients. 

While the component lists for the Advance and NeuroPro infant formulas seem comparable, the Enfamil NeuroPro has an edge because of a milk fat globule membrane (MFGM) compound.

According to Delene P. Musielak, M.D., a doctor in St. Louis, MFGM is a chemical that naturally exists in breast milk fat globule membrane and aids in this formula’s ability to resemble the qualities of breast milk or human milk more precisely. In addition, according to a study published in the Journal of Pediatrics, babies’ verbal, cognitive, and motor development were boosted by a milk formula that had added bovine MFGM and cow lactoferrin. There are a lot of options to choose from Similac Alimentum instead of going for a cow’s milk formula for your infant. Even though cow’s milk is well tolerated by most babies, some babies experience allergies upon taking a cow’s milk formula.

Which Infant Formula Is It?

Most pediatricians start babies out on standard non-fat milk-based infant formulas. Still, a doctor says that if parents report gas, digestive problems, colic and fussing, and lactose intolerance, they may suggest switching to gentle formulas.

Gentle or partially hydrolyzed formulas are simpler for small stomachs to digest since the milk’s protein molecules have already been disassembled. The size of the proteins in a gentle formula will be more similar to those in breast milk or human milk.

Similac’s Pro-Total Comfort milk utilizes just partially hydrolyzed whey protein, which may be easier for certain people’s stomachs. In addition, this milk has breast milk oligosaccharides (HMOs), prebiotics found naturally in breast milk that gives immunological, gastrointestinal, and cognitive support.

Meanwhile, Enfamil Gentlease contains partially hydrolyzed nonfat milk and whey protein concentrate, making it gentler on small stomachs. This partially hydrolyzed nonfat milk formula is designed for infants experiencing digestive pain and aims to relieve gas and the fussiness that often accompanies it. Get partially hydrolyzed nonfat milk if your infant is experiencing discomfort in digesting. 

Doctors recommend Pro-Total Comfort for lactose-intolerant babies. This version has HMOs and 2% lactose, compared to Gentlease’s 20%. In addition, Gentlease uses a partially hydrolyzed blend of 60% whey and 40% casein, whereas Pro-Total Comfort uses 100% partly hydrolyzed whey. Regardless of the comparison, both are great infant formulas for your baby. 

Is Similac considered a superior milk compared to Enfamil?

The Best Infant Milk For Spit-Up Relief

Enfamil vs Similac for spit-up? Spit-up is a natural aspect of becoming a new parent. The culprit is tiny, growing digestive systems, but with appropriate weight gain and enough wet diapers (six to eight per day), pediatricians frequently find no reason for alarm.

Compared to infants fed conventional nonfat milk-based formulas, Similac asserts that its spit-up formula decreases spit-up incidents in healthy, 2-month-old babies by 54%. In addition, this formula offers a combination of DHA, lutein, and vitamin E to boost newborn neurodevelopment and extra rice starch to help with spitting up. Babies can digest rice starch pretty well, which is why rice starch is used as an infant formula add-on for babies who suffer from frequent spitting up. Rice starch aids in digestion and thickens infant milk.

Enfamil AR is a rice-starch-enriched formula that claims to reduce spit-up in babies by up to 50%. This rice starch-enriched milk choice contains the same amount of DHA and ARA as the brand’s other formulations. Incorporating rice starch into gluten-free baking recipes can help improve texture and enhance the moisture retention of baked goods. Rice starch is known for its smooth and silky texture, making it a popular ingredient in Asian cuisine for thickening sauces and creating creamy desserts.

While the two infant formulas are pretty similar, Enfamil vs Similac, particularly in decreasing spit-up, Similac’s higher efficacy, combined with its reduced price, propels it to the first position.

Enfamil Vs. Similac

Both Enfamil and Similac manufacture products that will supply your infant with the nutrition they require. Many considerations will determine the brand you choose, including pediatrician advice, kind (cow’s milk-based, lactose-free, preterm, etc.), form (powdered milk, liquid concentrate, ready-to-feed), what your baby will accept, and cost.

If you’re looking for a hypoallergenic milk for your child, Similac has something for you. The Similac Alimentum Infant Formula with 2’-FL HMO is the first and only hypoallergenic infant milk with 2’-FL HMO, which is a unique immune-nourishing ingredient. The Similac Alimentum starts reducing colic symptoms due to protein sensitivity in most babies within 24 hours, which means that your infant can start feeling better after taking Similac Alimentum.

Whatever infant milk you choose, Enfamil vs Similac, know that the FDA has a rigid set of nutritional guidelines that each certified product must follow. Finally, milk selection depends on you and your baby’s preference. Infant milk is a specially designed alternative to breast milk, providing essential nutrients for the healthy growth and development of babies. Choosing the right infant milk is important for meeting your baby’s nutritional needs when breastfeeding is not an option.

There are various types of infant milk available, including cow’s milk-based, soy-based, partially hydrolyzed, and hypoallergenic formulas, allowing parents to find the most suitable option for their baby’s needs. Infant milk is carefully formulated to mimic the composition of breast milk, providing a balance of proteins, carbohydrates, fats, vitamins, and minerals.

FAQs – Is Similac Better Than Enfamil?

Can I Give My Baby Enfamil Instead Of Similac?

Enfamil vs Similac? If you’re still wondering what’s best between Enfamil and Similac, worry not because out of Enfamil Similac, both can be safely used for your infant.

Why Enfamil Is The Best?

Which Baby Formula Is The Best?

Enfamil vs. Similac: A comparison of these two popular infant milk brands helps parents choose the right option for their little one’s nutritional needs. When it comes to Enfamil vs. Similac, parents often weigh factors such as taste, ingredients, and affordability to make an informed choice for their baby. One key consideration in the Enfamil vs. Similac debate is the presence of prebiotics and probiotics, which can support a healthy digestive system in infants. Parents may also compare the different varieties offered by Enfamil and Similac to find the milk that best suits their baby’s specific dietary needs.

Which Formula Is Closest To Breast Milk?

The infant formula closest to breast milk is the one from Similac 360. Similac claims that they are the closest infant formula to breast milk. Similac infant milk has a blend of DHA, lutein, and Vitamin E which are nutrients found in breast milk. Breast milk is the natural and optimal source of nutrition for newborns and infants. Breast milk provides a unique blend of antibodies, enzymes, hormones, and other beneficial components that support a baby’s immune system. Breast milk is easily digested and tailored to meet the changing nutritional needs of a growing infant. Breast milk promotes bonding and emotional connection between the mother and baby during feeding.

Is Enfamil And Similac Safe?

Can You Gain Weight With Enfamil?

Why Do Doctors Recommend Enfamil?

What Are The Side Effects Of Enfamil?

Does Enfamil Help Brain Development?

Is Enfamil Safe For Infants?

Is Similac Safer Than Enfamil?
What Is The Advantage Of Enfamil Milk?
Can I Switch From Similac To Enfamil?
Is Enfamil FDA Approved?
Are Similac And Enfamil The Same Company?

Last Updated on April 12, 2023 by Faith Ann Maglantay

DISCLAIMER (IMPORTANT): This information (including all text, images, audio, or other formats on is not intended to be a substitute for informed professional advice, diagnosis, endorsement or treatment. You should not take any action or avoid taking action without consulting a qualified professional.   Always seek the advice of your physician or other qualified health provider with any questions about medical conditions. Do not disregard professional medical advice or delay seeking advice or treatment because of something you have read here a

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