Enfamil Gentlease Vs Similac: Which One Is Better?

A baby is known for having a sensitive tummy. Babies digestive systems are underdeveloped, especially infant kidneys, and not every formula is made to accommodate that. Some formulas make babies fussier or cause them to develop a severe allergic reaction. A different formula may have side effects compared to regular formulas or well-known formula brands. That is where the Similac Gentlease debate comes in, which a lot of parents prefer. In the article, we will compare enfamil gentlease vs similac and see if which one is the best.

Enfamil Gentlease vs Similac, which one is better? An image of milk inside a scoop.
Source: publicdomainpictures.net

When choosing an exclusive blend of sensitive infant formula that will help your child’s gut health as well, you usually have two options: Enfamil Gentlease and Similac Sensitive. Both of these best sensitive baby formula options are some of the top sensitive formula-based choices for the baby’s tummy. They are good for a child, and both Enfamil and Similac sensitive are good options.

Here, we’ll discuss Similac Sensitive vs Enfamil Gentlease, and whether or not Enfamil and Similac sensitive will help your child achieve complete nutrition, acquire vitamin D and other nutrients, good calcium absorption, and digestive health. We want to know the best baby formula for breastfed babies as well.

Similac Sensitive offers a formula that is known for being specially formulated to help babies with digestive issues. It contains coconut oil, high oleic safflower oil, and soy oil. Enfamil, their top competitor, released their own formula that is similar in nature, Enfamil Gentlease. Both of these formulas come with their good and bad things that parents need to know before choosing which one is the right formula for their little one. Take these things into consideration to find the perfect formula for your baby.

Enfamil Neuro Pro Gentlease Infant Formula-one of the best proven formula milk for your baby
Source: flickr.com

Every formula comes with a list of potential side effects. Often, these are listed on the side of the can. Other times, parents have to find out how it will affect their baby by trial and error, or by reading reviews from other parents. These are the most common side effects of both formulas.

Similac Sensitive Formulas

Common side effects include:

  1. Fussiness
  2. Gas
  3. Constipation Increased spit up

Enfamil Gentlease

Common side effects include:

  1. Diarrhea
  2. Explosive diarrhea
  3. Increased spit up
  • Enfamil Gentlease vs Similac Sensitive Version Results On Baby’s Digestive System

When you buy this formula, you’re searching for a formula that will help with your baby’s digestive problems, whether that is constipation, gas, mild spit-up, or difficulty digesting lactose. These are the most common results that other parents posted in their reviews.

  • Similac Sensitive Formulas

When you switch to Similac Sensitive, you won’t have to worry about diarrhea as much, but it seems to be common for babies to spit up more, sometimes with every bottle. On the flip side, you might have to worry about constipation or gas, the very things that this formula is supposed to prevent. Most parents can safely make the switch, though, and you can see positive results like less fussiness within a day of fully making the switch. This also contains the prebiotic 2 FL HMO (human milk oligosaccharides) for a stronger immune system.

Enfamil Gentlease Vs Similac, which is better? Image of Similac Sensitive Version For Fussiness & Gas Infant Formula-one of the best formula for your baby.
Source: flickr.com
  • Enfamil Gentlease

Most parents are a bit disappointed by explosive diarrhea, but it’s not usually bad enough that you are going to have to worry about your little one becoming dehydrated. Despite this, most moms are reporting that their babies are happier on Enfamil Gentlease than on other formulas. Through regular and frequent feedings, you can see a decrease in fussiness within a few days and many parents believe that this is the only formula for their little one.

Enfamil Gentlease is one of the few formulas with a partially hydrolyzed milk protein. What that means when it’s partially hydrolyzed is that the protein is broken up into larger pieces, so the partially hydrolyzed options offer more of a whey protein than even nonfat milk. Enfamil Gentlease infant formula contains vegetable oils, high oleic sunflower oils, and broken-down lactose proteins.

Partially hydrolyzed nonfat milk is a type of partially hydrolyzed option and partially hydrolyzed nonfat milk is something that makes it similar to cow’s milk. The one downside to partially hydrolyzed nonfat milk in a formula is for those who are allergic or have a reaction to milk or protein, they can’t have partially hydrolyzed nonfat milk since it will cause the allergy to flare up in many cases.

  • Price Of Enfamil Gentlease versus Similac sensitive Version

Both of these are popular baby formula brands, so you can expect them to be pricier than the store brand, but it’s always important to compare costs so that you get a formula that is right for both your baby and your bank account. TIP: Buying in bulk is an awesome way to save money if either of these seems to be out of your budget.

Price does vary depending on several factors, such as whether you’re opting for powdered formula or readymade formula. As a general rule of thumb, Enfamil is cheaper than Similac in almost every scenario.

Enfamil Gentlease VS Similac: Milk formula cans in the grocery.
Source: flickr.com
  • Enfamil Gentlease versus Similac sensitive Version Availability

Sometimes, a formula is not as readily available as you wish it was. For example, my grandson has to have Similac Neosure because he was born five weeks early. He also has a prescription for it. Unfortunately, most people in my city are on WIC, which has a contract with Gerber. That means that a lot of the stores around me don’t carry Similac Neosure. I’m stuck getting it at two stores or going out of town. Making sure that your choice is available nearby or online is a necessity.

It’s also important to make sure that the formula is available in your preference, like ready-made bottles, powder, or milk proteins for babies that are sensitive to milk.

Similac Sensitive

With the formula Similac Sensitive, you will get a milk-based baby formula that is easy to digest and doesn’t contain explosive diarrhea as the Enfamil formula do. This is the best formula for newborns who need something that is easy to digest, and with a milk protein isolate that is one of the tops on the market. Similac is incorporated with a good amount of fat protein blend essential for a child’s brain development.

It contains the A2 milk protein, which is a milk protein isolate not found in any other baby formula. The Similac Pro Sensitive Advance offers immune support in the milk protein, and with Similac Pro Sensitive Advance, you can also give your child brain and eye development nutrients from this milk protein. This can ensure complete nutrition for your baby.

Similac Pro advance has a milk protein isolate that is not made with artificial flavors, and the protein isolate in it is easy to digest, so is great for those with sensitive stomachs. The pro advance also comes with no artificial growth hormones in it either, so it is a baby formula that provides a protein isolate that will help a child.

Similac Pro Sensitive infant formula is similar to Similac Pro Sensitive advance in that it has some of the same protein isolate and milk protein contents that the pro advance formula does, but it is a baby food that is easy to digest and is the best best baby formula for constipation and sensitive stomachs.

You also have Similac Total Comfort, which is the best one for those who want a baby formula that contains a protein isolate and milk protein that will help your child, but also is great for comfort and is a baby formula option that’s great for digesting.

Similac Sensitive is a great milk-based baby formula that will provide a variety of different milk protein compounds that will help the child. While it can make a child fussy, usually this baby formula is the best one out there for this, and you’ll definitely love the results you get from it.

Different milk formula for baby. Check the things you need to know about these formulas.
Source: commons.wikimedia.org


Enfamil Gentlease can be ordered online and can be found at most major retailers. When it comes to variety, Enfamil Gentlease takes the cake. It can be found in single-serving packets, ready-to-eat bottles, powdered formula, bulk cans of powder, and already-made canisters. If you have a preference, this one has got you covered.  Enfamil Gentlease is similar to Similac formulas, but it also offers a baby formula with a milk protein and a milk protein isolate that is easy to digest.  It is the best formula for baby option because this milk-based formula with fat protein blend is easy to digest, and offers a lot of options. The Beauty of Enfamil formula is that with this, you’ll get a variety of baby formula options to help your child. And whether you want something similar to human milk or with a milk protein isolate that works for them, this is one of the best for you to consider.

Enfamil Enspire

While formula Enfamil Gentlease is one of the easiest infant formulas for the stomach, Enfamil Enspire is the closest you will get to human breast milk. This is great for children who are weaning off breast milk, because Enfamil Enspire contains milk and whey protein concentrate solids in this baby formula that will help the child get all the vitamins and minerals that they might get out of breast milk.

For some infant formula, especially milk-based infant formula, you want something that is similar to breast milk, and luckily, Enfamil Enspire offers that.  Enfamil Enspire, it contains a milk-based protein that is commonly found in breast milk, which is designed to not only help with brain development but also offer the same nourishments that you will get in breast milk.  With Enfamil Enspire, you’ll be able to offer the breast milk benefits without breast milk, and the traditional milk protein formula within Enfamil Enspire offers significant healthy growth, and it is easy to digest.

This is the best baby formula for those looking for something that is easy to digest, but also is similar to breast milk in terms of milk based protein options. Enfamil Enpsire is an infant formula made to provide the similar nutrients that breast milk does, but is also a baby food that will give a child everything they need.

Enfamil Gentlease Enspire for easing gas, fussiness and crying
Source: flickr.com

Enfamil Neuropro Gentlease

As a bonus, Enfamil Gentlease is also available in Neuropro form. This gentle milk powder formula has all the vitamins (like vitamin e, k, and B2), fat protein blend mfgm, and nutrients that are commonly found in breastmilk. According to the advertisements, it can reduce fussiness and gas in a quick 24 hours. According to customer reviews, it works most of the time. It does come with the same side effect of explosive diarrhea, though.

Enfamil Neuropro Gentlease is great for babies with sensitive stomachs, and many parents like Enfamil Neuropro because not only does it help with sensitive tummies, but also offers a simple formula to build cognitive and brain development. Enfamil Neuropro Gentlease does come with vitamins (like vitamin e, k, and B2) and minerals in this infant formula, and it does have a similar makeup to breast milk. Enfamil Neuropro infant formula does contain a protein isolate in there, and it can sometimes create diarrhea in the baby. But it is a baby formula that’s similar to breast milk, and this protein isolate can help build development. Some people like the Neuropro infant formula because the milk protein in it will help with improving the baby’s cognitive development, and it is considered one of the best baby formulas out there since it is easy to digest for most children. The Neuropro Infant formula is best for cognitive and brain development. On the other hand, if you’re looking for thicker formulas that can help with reflux, then Enfamil AR may be a good option for your baby. Enfamil Nutramigen baby formula is suited for an infant who has a cow’s milk protein allergy. A cow’s milk protein allergy is an allergy caused by a reaction in cow’s milk, in cases such as these, you opt to buy a gentler formula out there. This formula is also good for those who are lactose intolerant since it is hypoallergenic and lactose-free at the same time. If you’re looking for reduced lactose formulas out there, then search no more. There are a bunch of lactose-free formulas like Enfamil, Similac, Baby’s Only Lactorelief Organic Formula, and many more that contain essential fatty acid from vegetable oil. If your gassy baby is experiencing symptoms such as diarrhea, tummy ache, or gas then it’s a sign to buy reduced lactose formulas. Your child might have lactose intolerance so it’s better to use a lactose-free formula. On the other hand, if your baby has acid reflux then you may opt for Enfamil AR. Enfamil AR is a specially made formula for babies with acid reflux. Formulas with partially hydrolyzed protein can be easily broken down which makes it effective in reducing acid reflux and infants with food allergies. There are many formulas out there that can help with a gassy baby differently, such as reduced lactose formulas that contain essential fatty acid from vegetable oil. When choosing a baby’s formula, it’s important to consider their individual needs and consult with a pediatrician if necessary.

Enfamil Neuropro Infant Formula
Source: flickr.com


Both Enfamil and Similac are great infant formula options for you to try, and they do offer a great baby formula to help with this. It’s pretty easy to find a store that carries this, and they even offer gift cards and vouchers for those looking to save a bit of money on an infant formula.

Whichever formula you choose for your baby, just remember to never let him drink soft drinks!


Enfamil Gentlease VS Similac: Frequently Asked Questions (FAQs)


What is the Gentlease formula used for?

Gentlease formula is used to reduce fussiness, gas, and other symptoms of an upset stomach in infants.   Tummy aches might be caused by natural sugar lactose. Enfamil Gentelease is said to be good for those who have lactose sensitivity because Enfamil products do not have high fructose corn syrup (HFCS). Instead of using high fructose corn syrup as a source of carbohydrates, Enfamil uses corn syrup solids instead. Keep in mind that corn syrup solids are not the same as HFCS. Corn syrup is believed to be an essential source of energy which is why infant formulas make use of corn syrup solids. Corn syrup solids are recognized as safe by the FDA, the concept of corn syrup harmful is only a myth. Make sure to consult a pediatrician for clarification if your baby has lactose sensitivity.

Enfamil Gentlease VS Similac: What formula is easiest on the baby’s stomach?

When it comes to the easiest, Similac vs Enfamil Gentlease? The answer is Enfamil. It doesn’t cause diarrhea, parents report that their babies are still happy and they do not cry as much, leading us to believe that it’s easier on the baby’s stomach. On the other hand, Similac for Spit-Up is good for babies with acid reflux.

Source: pikrepo.com
Similac Pro-Sensitive Infant Formula
Source: flickr.com

Is Enfamil easier to digest than Similac sensitive?

Both of them are easy to digest due to the ingredient that is called corn syrup. Both Enfamil and Similac Formula have corn syrup in their baby formulas. It is not a myth that Enfamil has corn syrup solids, Enfamil formulas, have a type of corn syrup starch that is known for making them easier to digest than other formulas, Corn syrup solids are believed to be safe (corn syrup harmful is only a myth) and approved by the FDA which is why both Enfamil and Similac has it. However, this can cause an upset stomach in some babies. Consult a pediatrician if you think corn syrup has a negative effect on your baby.

Which Similac formulas are similar to Enfamil Gentlease?

The Similac Sensitive formula that is the most similar to Enfamil Gentlease is the Similac Pro-Sensitive. The Similac Pro Sensitive Infant Formula and Enfamil Gentlease are said to have quite a few similarities. Both of them are rich sources of DHA which is essential for the brain and eye development of an infant. Similac formulas are palm olein oil free, while Enfamil AR uses palm olein oil as one of its ingredients.

Why is Enfamil Gentlease so foamy?

The reason why formulas like Enfamil Gentlease tend to be foamy lies on the preparation and making process.  If you mix the powder with water and shake it, it is just normal to end up with foams and bubbles as a result. But some formulas tend to be foamier than others, and this is quite alarming to some since too much foam may cause digestion issues in your infant.

Which formula is closest to breast milk?

The formula that is said to be the closest to breast milk is the Enfamil Enspire. Enfamil Enspire has protein ingredients like lactoferrin which can be found in colostrum. Aside from that, it also has DHA, choline, milk fat globule membrane, vitamin e, and other vitamins and minerals which are essential for your baby’s healthy growth. Pick a formula that can offer complete nutrition for your infant.

Can I mix Similac Pro Sensitive and Enfamil together?

Yes, it is safe to mix Similac Pro Sensitive and Enfamil together, as well as the best baby cereal to mix with formula. Formula companies are aware that it’s safe to mix two formulas together. Just make sure to follow the standard mixing instructions included in the manual or label. If you’re still worried about mixing two formulas, better consult and pediatrician or professional.

Does Gentlease cause constipation?

No, Gentlease doesn’t cause constipation. In fact, Gentlease is clinically proven in easing the fussiness and gassiness of your babies. It also helps by encouraging daily bowel. Enfamil brands are formulated with prebiotic blends which support digestive health and soft, comfortable stools for infants. If your infant is experiencing a gassy tummy–a gassy baby, then you should opt for gentle formulas. Experts also recommend switching to hypoallergenic formulas if you’re baby is prone to allergies.

What formula do hospitals use for babies?

Similac is the leading infant formula brand that most hospitals recommend to be used. It is also among the hypoallergenic baby formula brands out there. This baby formula belongs to organic formulas which are clinically proven to cover all of your baby’s needs. Similac contains HMO or Human Milk Oligosaccharide which is a prebiotic similar to what can be found in human milk (breastmilk), it also has no artificial growth hormones. Organic formulas are good since it doesn’t have any artificial ingredients and artificial growth hormones which may be harmful to babies. Aside from Similac, there are a lot of organic formulas to choose from out there.

Is Enfamil Gentlease cow milk-based?

Yes, Enfamil A+ Gentlease is a cow’s milk-based infant formula. But similar to another infant formulas, this is still easy to digest proteins by babies. Cow’s milk protein is believed to contain lots of calories and vitamins that your baby needs. After using infant formulas, you can switch to giving cow’s milk protein to your baby. Just make sure it’s full-fat cow’s milk rather than skimmed cow’s milk. If your infant happens to have a cow’s milk allergy, better to opt for a hypoallergenic formula or a lactose-free formula. Lactose-free formulas are best for those with lactose sensitivity and lactose intolerance. There are a lot of lactose-free formulas out there, just pick which lactose-free formula is the best for your kid.

Which is more better Similac or Enfamil?

Is it OK to switch from Similac to Enfamil?

What is the generic brand for Enfamil Gentlease?

Which type of Enfamil is best?

Is Enfamil Gentlease FDA approved?

Enfamil Gentlease And Similac Version Other Resources

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Last Updated on May 14, 2023 by Cath Aguinaldo

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